Invention to the topic life science:
1  Diagnosis and treatment of Alzheimer´s and other neurodementing dseases
A-beta-autoantibodies were isolated from the serum of Alzheimer patients. The cDNA and amino acid sequences of the variable regions of the heavy and the light chains were determined and all possible pairings of the chains were expressed in mammalian cells.
A number of these pairings were found ....
LS_014[2009] [abstract]   [full text] 
2  Diagnostic and therapy of the complex regional pain syndrome
Our scientific studies of biological samples derived from CRPS patients demonstrated for the first time that the onset of CRPS is caused by autoantibodies against specific receptors, which activate these receptors and elicit, in the context of an autoimmune disease, neuronal inflammatory reactions. ....
LS_012[2009] [abstract]   [full text] 
3  Prophylaxis and treatment of the skin disease pityriasis
Scientific research concerning the pathogenesis of pityriasis at the University of Giessen demonstrated that the disease-initiating event in pityriasis is the synthesis of pigments and fluorochromes which is dependent on one single enzyme. Inhibitors of this enzyme were identified which completely s....
LS_011[2009] [abstract]   [full text] 
4  Protein RPS19 for the treatment of inflammatory diseases and cancer
With respect to both structure and function, the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) is a unique mediator of the immune system, whose important role in inflammatory diseases such as septic shock, chronic inflammations and autoimmune diseases such as arthritis, glom....
LS_010[2009] [abstract]   [full text] 
5  Procedure for the Production of Insulin in Stem Cells
For the induction of insulin synthesis, placental stem cells are used since the placenta possesses several pluripotent cells which can be isolated in large numbers without ethical problems or stress for mother and child. These include primarily chorion cells which are cultivated using a specific ....
LS_003[2009] [abstract]   [full text] 
6  Specific detection of Mycobacterium avium ssp. paratuberculosis (MAP)
Up to now, the detection of Mycobacterium avium ssp. paratuberculosis is very difficult and infections can unfortunately only be confirmed in a very late stage. Consequently, from time to time contaminated food products (e.g. milk) could be released to market which may possibly become a health risk....
LS_001[2009] [abstract]   [full text] 
7  Cell line from pregnant bovine uteri - in vitro assays for the detection of disorders of pregnancy-related processes
The present maternal caruncular epithelium cell line allows for novel and specific in vitro in-vestigations concerning the physiology and pathology of reproduction in cattle.
At present, all studies on disorders of pregnancy related processes in the placenta are only performed in vivo, exclusiv....
LS_017[2008] [abstract]   [full text] 
8  Plasminogen activator for the treatment of acute inflammatory and chronic interstitial lung diseases
Production of a recombinant chimeric fusion protein, consisting of human plasminogen activator (urokinase or u-PA) and human hydrophobic surfactant protein (SP-B, SP-C).
Persistent suppression of alveolar fibrinolytic activity and the resulting permanent intra-alveolar fibrin deposition play an....
LS_016[2008] [abstract]   [full text] 
9  Methods for detecting early stages of Mycobacterium avium subsp. paratuberculosis (MAP) infections - also suitable for calves
Two new methods allow the specific and sensitive detection of Mycobacterium avium subsp. paratuberculosis (MAP) infections in normal blood samples, even in early stages of disease where animals exhibit clinical symptoms and in blood samples taken from calves.
Both methods involve flow cytometry....
LS_014[2008] [abstract]   [full text] 
10  Tumor therapy in dogs with interleukin-releasing cell lines*
For the treatment of the majority of tumors diseases in dogs, only classical procedures by surgical removal of the tumor, radiation and chemotherapy are available, the development of new and patient-friendly therapy concepts is indispensable. A new therapeutic strategy provides for the use of biolog....
LS_009[2008] [abstract]   [full text] 
11  Reliable Inactivation of Hepatitis B Virus
The new "in vitro" test with hepatocyte cultures isolated from Tupaia sp. (Southeast Asian tree shrews) and highly concentrated hepatitis B virus fractions demonstrates the efficacy of inactivation procedures achieving titer reductions by more than 4 log 10 dilution steps, thus meeting the guideli....
LS_007[2008] [abstract]   [full text] 
12  Biomarkers for Diagnosis of Parkinson’s Disease in Skin Biopsies
Expression analysis of several novel biomarkers in skin probes of patients allows the prognosis and diagnosis of all variants of Parkinson’s disease (PD), monitoring of the disease progression and the response to medical treatment.
LS_020[2007] [abstract]   [full text] 
13  Screening Assay for Diagnosing the sensitivity of patients to pain
A high-throughput screening assay allows the analysis of two DNA positions of GTP cyclohydrolase 1 (GCH1) gene to predict the sensitivity of patients to pain and their risk of developing chronic pain.
LS_018[2007] [abstract]   [full text] 
14  Modulation of neural stem cells by use of EGFL7 or EGFL7 antagonists
Scientists from the university hospital of Frankfurt am Main prove for the first time, that the signalling protein EGFL7 binds to notch receptors and regulates the self renewal of neural stem cells. Therefore, EGFL7, EGFL7 antagonists and EGFL7 antibodies can be used to grow specialised cells and ti....
LS_016[2007] [abstract]   [full text] 
15  Novel medical indication of Baclofen and other GABAB receptor specific agonists
Scientists from the university hospital of Frankfurt am Main found that baclofen significantly improves the medical therapy in a so far unknown field of medical application. Furthermore, the results implicate that other GABAB receptor specific agonists hold a comparative potential. The new indicatio....
LS_014[2007] [abstract]   [full text] 
16  Protein P4 (SLC10A4) as a marker protein for cholinergic neurons of the CNS
The protein SLC10A4, also known as P4, occurs in numerous cholinergic neurons. Up to now, however, a method that allows for the detection of SLC10A in cholinergic neurons does not exist.

The invention at hand discloses a procedure for the detection of cholinergic neurons in the CNS by means of....

LS_008[2007] [abstract]   [full text] 
17  Protein for the chemoenzymatic production of L-threo-hydroxyaspartate
The invention at hand provides a novel protein for the chemoenzymatic and enantiomerically pure production of L-threo-hydroxyaspartate from L-aspartate.

The naturally occurring protein AsnO (asparagine oxygenase) is part of the CDA biosynthesis gene cluster in Streptomyces coelicor. Asn....

LS_006[2007] [abstract]   [full text] 
18  cDNA-Synthesis from cells after microdissection
• Specially developed procedure for the analysis of individual eurons from fixed brain cross sections is applicable for a multitude of other cell types and tissues • Contamination free isolation of individual cells from fixed tissue by means of laser microdissection and subsequently, the direct ....
LS_004[2007] [abstract]   [full text] 
19  Improved Detection Limits of Solid-Phase Micro-Extraction
The detection limits of trace analysis with a previous SPME-enrichment step can be improved by a factor of four to five thanks to the new inventive process.
LS_002[2007] [abstract]   [full text] 
20  Multivalent chelator molecules for handling and manipulating recombinant proteins
The novel multivalent chelator molecules which consist of flexible scaffolds and several independent chelator groups enable purification, detection and manipulation of accordantly tagged proteins in living and fixed cells as well as in lipid vesicles. Furthermore, a usage to build up biosensors or p....
LS_020[2006] [abstract]   [full text] 
21  Selective Synthesis of Dihydroxyacetone using an Oxidisation Catalyst
The invention relates to a method for the fabrication of dihydroxyacetone (DHA) using a new catalyst which facilitates a selective oxidisation of glycerol. Furthermore, a method for the making of the catalyst is presented.
LS_018[2006] [abstract]   [full text] 
22  Pest control of parasitic plant Cuscuta
The invention introduces a specific pest control of parasitic Cuscuta, also called dodder, which prevents investation of host plants and reliably eliminates attached dodder plants by applying a specifically active peptide that inhibits penetration of dodder’s haustoria into host plants.
LS_014[2006] [abstract]   [full text] 
23  Reagent-free, high throughput method to analyse different compounds in body fluids
The invention consists of a device and method for fast quantitative measurements of compounds, like glucose, urea, cholesterol, of body fluids, e.g. blood or urine.
LS_013[2006] [abstract]   [full text] 
24  Process for the manufacturing of a chemically modified protein
There are already several methods for the introduction of modifications in proteins which make use of the particular nucleophilicity of the cysteine side chain. Some of them are based on the fusion of two intein fragments to generate an active intein. However, the methods known so far are not regios....
LS_011[2006] [abstract]   [full text] 
25  Anisometric particles for the pulmonary application of active agents
Inhalation therapy provides any advantages in comparison to the oral or intravenous application of drugs Pharmaceutically active agents can very often be applied to the site of action in a more targeted manner by means of inhalation, whereby the dose can be reduced in comparison to other application....
LS_009[2006] [abstract]   [full text] 
26  Method for the prediction of sepsis
For the establishment and evaluation of expression profiles generated from the blood of patients with infections, for the first time clinical and genomic data are taken into account, allowing a particularly early diagnosis of septicaemia and/or septic states. An anticipated septic reaction can alrea....
LS_004[2006] [abstract]   [full text] 
27  In vitro method for the diagnosis of acute leukaemia
In order to guarantee a routine diagnosis and effective therapy care of high-risk-leukaemia-patients a reliable, extensive and fast diagnostic procedure is required. The presented innovation covers these advantages. The in-vitro technique identifies chromosomal translocations of the MLL-gene with ge....
LS_020[2005] [abstract]   [full text] 
28  Biodegradable carrier systems for plant protection products and a method for their release
The novel method employs the well known electrospinning technology in order to use completely biodegradable polymers (e.g. made of lactic acids) for coating of plant protection products. The cultivated plants to be protected are encased according to the novel method and its device with a fine web of....
LS_018[2005] [abstract]   [full text] 
29  Protein-rich foodstuff
The invention is for a protein-rich plant foodstuff and a process for its production. The aim of the invention is to create a foodstuff that has the same amount of protein but lower fat content and is fruit-based and can be cultivated in central Europe. The residues of rape oil production can be use....
LS_017[2005] [abstract]   [full text] 
30  Substances for the treatment and prophylaxis of macular degeneration
Age-related macular degeneration (AMD) is differentiated into a “dry” and a “wet” form of progression. With approx. 85 % of cases, dry AMD occurs far more often. With this form of the disease, over a period of several years, loss of light-sensitive cells in the retina occurs. One cause, amongst othe....
LS_015[2005] [abstract]   [full text] 
31  Novel instrument and methods for the accelerated re-ossointegration of dental implants
The novel instrument for the accelerated re-osseointegration of dental implants resembles, at its core, a novel dental drill (dental drilling device) and is available in many embodiments. For improved preparation and subsequent re-osseointegration of dental implants, all embodiments of the novel dri....
LS_013[2005] [abstract]   [full text] 
32  Ratio between PlGF and Flt-1 as a prognostic tool for cardiovascular diseases
The invention uses the significance of the biochemical markers PlGF and Flt-1 for risk stratification of people with a cardiovascular disease or for the evaluation to develop such a disease. The method involves the quantification and calculation of the ratio of PlGF / Flt-1 in a sample derived from....
LS_011[2005] [abstract]   [full text] 
33  Diagnostic method for the determination of cardiovascular functionality of specific progenitor cells
The method enhances the diagnostic and therapeutic care of patients with coronary heart diseases. With assistance of the inventive method patients can be identified showing low capacity of neo-vascularisation of their stem and progenitor cells which would weaken the success of cell therapy. At the ....
LS_009[2005] [abstract]   [full text] 
34  Proteinmarker/ Biotech
This invention concerns protein analysis. An important method in protein biochemistry is the analysis of protein molecular weight based on migration in an electrical field. Marker proteins of known molecular mass are co-electrophoresed to serve for calibration and for the establishment of a calibra....
LS_008[2005] [abstract]   [full text] 
35  sCD40L as a biochemical marker for cardiovascular diseases
sCD40L is a biochemical marker for the identification of activated platelets of patients with cardiovascular diseases (angina pectoris, infarction, stroke etc.). The concentration of sCD40L is determined by rapid analysis of peripheral blood samples. Serum levels of sCD40L are already raised before....
LS_005[2005] [abstract]   [full text] 
36  Manufacture of CLA by silver/supported catalysts
The invention describes a manufacturing method of conjugated fatty acids or its derivates by isomerisation of non-conjugated fatty acids or fatty acid derivates. The non-conjugated fatty acid or its derivate is treated with a supported silver catalyst, which has previously been activated with hydrog....
LS_004[2005] [abstract]   [full text] 
37  Inhalative administration of fibrinogen IIb/IIIa receptor antagonists for prompt acute therapy in the event of thrombus formation
The effect of the intravenously administered fibrinogen IIb/IIIa receptor antagonist Tirofiban as a thrombocyte aggregation inhibitor is known and well investigated. Now, for the first time, the dispersal of Tirofiban in the form of an aerosol has been achieved, which allows application of the produ....
LS_002[2005] [abstract]   [full text] 
38  Biodegradable colloidal particles for inhalative administration
Inhalative administration is an important method of application for medications and active ingredients for the treatment of pulmonary diseases.

Now nanoparticular transport vehicles are available, which absorb active ingredients and release them at the desired location, i.e. the lungs. In....
LS_001[2005] [abstract]   [full text] 
39  Growth Factors - Activation via Phosphate Donors
Growth factors are important key proteins which have different trophic, protective and degenerative effects on target cells as well as on cell-cell-communication and form part of the intracellular signal transduction. They support, for example, not only cell proliferation, migration and vitality, bu....
LS_039[2004] [abstract]   [full text] 
40  Highly specific DNA-interacting enzymes with programmable specificity
Different enzyme families are used in vitro and in vivo for the manipulation of DNA. Restriction endonucleases, exonucleases, DNAseI, DNA repair enzymes and DNA methyltransferases, amongst others, belong to these enzyme families. However, the targeted and exclusive addressing of specific individual ....
LS_037[2004] [abstract]   [full text] 
41  Equine Inhalation Mask
Since horses commonly suffer from illnesses of the upper respiratory tract, an effec-tive inhalation therapy can help avert financial losses for race/sports horse owners. The equine inhalation apparatus that are currently available all contain probes that have to be fed into the animal’s nose. Durin....
LS_033[2004] [abstract]   [full text] 
42  Apparatus for Tissue and Organ Manipulation
The invention is an apparatus for puncturing or for carrying out other forms of manipulation of human tissue whereby the anchorage of the tissue is reliably recognised and signalled. The invention in question enables, in particular, access to the pericardium after it has been punctured. The apparat....
LS_032[2004] [abstract]   [full text] 
43  New bioreactor for cultivation and pressure stimulation of cells and cell-matrix-composites
The invention concerns new bioreactor systems for cultivation and pressure stimulation of cell-matrix-composites. A special aspect of the invention is that the device is composed in a way that generally available tissue culture plates (with up to 96 cavities) can be used as part of the new bioreact....
LS_031[2004] [abstract]   [full text] 
44  GLP-1 and exendin derivatives in the diagnosis of diabetes mellitus and in the diagnosis and therapy of tumours
With the new GLP-1 and exendin-3 /-4 derivatives, as well as chimeric peptides from GLP-1 / exendin or exendin / GLP-1 respectively, peptides are available which are recognised and specifically bound by neuroendocrine GLP-1 expressing tumours, such as insulinomas, carcinoid tumours and small cell br....
LS_028[2004] [abstract]   [full text] 
45  Antithrombin III therapy of angiogenesis-dependent diseases
During growth, tumours secrete enzymes, which proteolytically cleave known proteins, such as collagen XVIII and antithrombin III (AT III), or alter their conformation (e.g. to latent AT III). The fragments formed in this way (cleavage products) show in vitro and in vivo antiangiogenic properties and....
LS_026[2004] [abstract]   [full text] 
46  Novel amino adamantane compounds and 3-amino adamantane 1-carboxylic acids
All previously known synthesis procedures for the production of adamantane derivatives require drastic reaction conditions like, for example, the use of concentrated acids and high temperatures. Thus, the range of functional groups that can be introduced is starkly restricted. Above all, from the gr....
LS_021[2004] [abstract]   [full text] 
47  Subcloning of nucleic acid fragments
The invention deals with subcloning of a nucleic acid fragment from a source vector into any target vector. It can be carried out in one step; the result is available within a few hours, easy to handle, independent from the type and sequences of the target vector, and independent from resistance mar....
LS_014[2004] [abstract]   [full text] 
48  Detection of BSE risk material
Species-specific and simultaneous, quantitative detection of BSE risk material in meat and meat products based on a new real-time PCR-method BSE belongs to the sphere of types of transmissible spongiform encephalopathy (TSE), which can develop in humans due to misfolded protein bodies, so-called ....
LS_013[2004] [abstract]   [full text] 
49  Influenza - Production of a live attenuated influenza virus vaccine
With a novel method it is possible for the first time to produce a live attenuated influenza A virus vaccine. The method is based on the production of specific mutants of influenza viruses which in vivo are in fact immunogenic, but not pathogenic. Their genome largely corresponds with that of the cu....
LS_012[2004] [abstract]   [full text] 
50  RNA aptamers in sepsis therapy
Aptamers are special nucleic acids with structural characteristics which allow them to bind to a specific protein as a target molecule. Selected RNA aptamers with a characteristic lead structure already exist, which bind specifically to the murine, lipopolysaccharide-binding protein (mLBP). This pro....
LS_011[2004] [abstract]   [full text] 
51  Gene transfer system specific for endothelial cells
Viral gene transfer systems consisting of replication-deficient pseudo-type viruses which carry the VEGF on their envelope are suitable for the introduction of at least one gene into patients and can be applied in gene and tumour therapy. Features: Specific implementation in the vascular system, ....
LS_010[2004] [abstract]   [full text] 
52  Refillable Microsensor for the Enzymatic Measurement of Gases in Biological Samples
The invention deals with a microsensor for the enzymatic measurement of gases in biological samples. An outer micropipette contains a silicone gasket being highly permeable to gases and a reservoir for the enzyme solution. The reservoir is formed like a discharge chamber and hence allows for exchang....
LS_007[2004] [abstract]   [full text] 
53  Fluorescence dye made of plant extracts for the staining of eosinophilic leukocytes
The natural dye extracted from plants containing physcion is suitable for the staining of lipophilic cell components in biological samples, preferentially for the staining of eosinophilic leukocytes in whole blood smears. In aequous solutions, the natural dye invades living cells and stains the cell....
LS_005[2004] [abstract]   [full text] 
54  Clot Lysis Assay – measurement of fibrinolysis in all parts of the reaction
At present, the fibrinolysis system is measured chromogenically via the enzyme activity of plasmin as a matter of routine. As the last reaction of fibrinolysis, i.e. the dissolution of fibrin strains, cannot be detected, this measurement system is only in part physiologi-cal. The invention on han....
LS_004[2004] [abstract]   [full text] 
55  Chronic inflammatory diseases - manufacturing of a specific drug
The invention on hand deals with a drug against chronic inflammatory diseases which is specific for a cell or tissue type, a particular disease or a particular disease stage. Proteins and nucleic acids that are specific for a disease, a cell type, a tissue or a disease stage are identified with rega....
LS_002[2004] [abstract]   [full text] 
56  Nebulisable liposomes - Method for the pulmonary delivery of agents
The treatment of lung and respiratory diseases, such as asthma and Chronic Obstructive Pulmonary Disease (COPD), pneumonia and pulmonary hypertension, is carried out by means of agents with a long biological half-life. Liposomes are favoured that remain as stable as possible during nebulisation and ....
LS_020[2003] [abstract]   [full text] 
57  PCR detection procedure for carcinoma cells
The gene GA733-2 is known to code for a glycoprotein on human epithelia and on a majority of carcinoma cells. What is dealt with here is an adhesion molecule that has a multitude of names and among other terms, is also called 17-1A-antigen. With the help of the PCR procedure, individual epithelial c....
LS_019[2003] [abstract]   [full text] 
58  Invention concerning surgical drapes
The invention concerns a surgical drape, espacially for surgical interventions on the brain or head. These novel drapes are provided to cover two areas. First the sterile cover of the area of surgery and additionally the steril cover for a surveying system, espacially with infrared radiation. Pre....
LS_017[2003] [abstract]   [full text] 
59  Time saving procedure for gene assisted selection in dairy breeding
Advantage: High accuracy of forecast, breeding values within 24 hours instead 4 years, cost reduction compared to the conventional test mating of young bulls. Concept: The new procedure provides a useful tool for the selection of breeding animals with gene variants having proven positive effect o....
LS_015[2003] [abstract]   [full text] 
60  Device for long-term microscopical analysis of living cells
The device permits the uncomplicatet realization of long term analysis of living cells under the microscope. The device exists, according to the demand of the medium, in different designs. In general it consists of a holding device which is on the ground of the object carrier and a cover glas that i....
LS_013[2003] [abstract]   [full text] 
61  Pedal ergometer (MR_PEDALO) for a defined stress examination of the lower leg muscles
The device will be operated by a modular composed measuring station combined with a dynamic nuclear spin tomograph, a software to analyse the measurement of the blood cir-culation, the measuring apparatus of the device and a software to analyse the muscle acit-vity. With the aid of the pedal ergomet....
LS_012[2003] [abstract]   [full text] 
62  System for the examination of the cerebral autoregulative capacity
The invention concerns a device for examination and a software to control and evaluate. It is used for the employment in vetenerian medicine or for pharmaceutical studies. It can be used for description or for tests of the cerebral autoregulation higher mammals. The main field for operation is the u....
LS_011[2003] [abstract]   [full text] 
63  Microsensor to Measure the Cellular Photosynthesis and the Respiration in Leaves
A microsensor with a new type of silicone gasket permits for the first time the direct and continuous determination of gases beyond single stomata of leaves. The gasket, located in the point of an outer micropipette, is highly permeable to gases. An enzyme solution beyond the gasket converts the gas....
LS_008[2003] [abstract]   [full text]